A one-pot asymmetric organocatalytic tandem reaction for the synthesis of oxazine derivatives.
نویسندگان
چکیده
An easy one-pot tandem reaction catalyzed by a chiral secondary amine for the synthesis of optically active oxazine derivatives has been performed and the corresponding substituted benzo[d]pyrido[2,1-b][1,3]oxazine derivatives were afforded in generally high yields (up to 99%) and excellent enantioselectivities (up to >99%).
منابع مشابه
A Facile One-Pot Solvent-Free Synthesis of 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones Catalyzed by Nano-Fe2O3
One of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. The present study aimed to use a method for the synthesis of some 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. The question this study tried to answer was this reaction can be performed in present of nano-Fe2O3 as an acid catalyst an...
متن کاملA Facile One-Pot Solvent-Free Synthesis of 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones Catalyzed by Nano-Fe2O3
One of the most important goals in medicinal chemistry is the development of new techniques and new heterocyclic compounds with pharmaceutical activity. The present study aimed to use a method for the synthesis of some 1,2-Dihydro-1-arylnaphtho [1,2-e] [1,3] oxazine-3-ones. The question this study tried to answer was this reaction can be performed in present of nano-Fe2O3 as an acid catalyst an...
متن کاملTiO2 Nanoparticles: A Potent Heterogenous Nanocatalyst Mediated One-Pot Tandem Approach for the Environmentally Friendly Synthesis of 3,4-Dihydropyrimidin-2-(1H)-One/Thione Derivatives Under Solvent-Free Conditions
This procedure has developed the use of TiO2 nanoparticles as an environmentally friendly and highly efficient heterogenous nanocatalyst for the eco-safe, facile and one-pot three-component Biginelli synthesis of biologically active corresponding 3,4-dihydropyrimidin-2-(1H)-one/thione derivatives under solvent-free conditions. This eco-friendly protocol provi...
متن کاملUrea-hydrogen peroxide/silica phosphoric acid-catalyzed oxidation- condensation Tandem reaction: One-pot synthesis of 2-substituted benzimidazoles from alcohols
An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalyst. This method provides a rapid and efficient access to 2-substituted benzimidazoles.
متن کاملUrea-hydrogen peroxide/silica phosphoric acid-catalyzed oxidation- condensation Tandem reaction: One-pot synthesis of 2-substituted benzimidazoles from alcohols
An efficient one-pot oxidation/condensation tandem process has been developed for the synthesis of 2-substituted benzimidazole derivatives from benzylic alcohols and 1,2-phenylenediamine with use of urea-hydrogen peroxide/silica phosphoric acid as a bifunctional catalyst. This method provides a rapid and efficient access to 2-substituted benzimidazoles.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 9 6 شماره
صفحات -
تاریخ انتشار 2011